Substituted benzamides

A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I

• wherein
• R is hydrogen or lower alkyl;
• R1 is —(CH2)n—(O)o-heterocycloalkyl or —C(O)-heterocycloalkyl, wherein the heterocycloalkyl group is optionally substituted by lower alkyl, hydroxy, halogen or by —(CH2)p-aryl;
• n is 0, 1 or 2;
• o is 0 or 1;
• p is 0, 1 or 2;
• R2 is CF3, cycloalkyl, optionally substituted by lower alkoxy or halogen, or is indan-2-yl, or is heterocycloalkyl, optionally substituted by heteroaryl,
• or is aryl or heteroaryl, wherein the aromatic rings of the aryl or heteroaryl are optionally substituted by one or two substituents, selected from lower alkyl, halogen, heteroaryl, hydroxy, CF3, OCF3, OCH2CF3, OCH2-cycloalkyl, OCH2C(CH2OH)(CH2Cl)(CH3), S-lower alkyl, lower alkoxy, CH2-lower alkoxy, lower alkynyl or cyano, or by —C(O)-phenyl, —O-phenyl, —O—CH2-phenyl, phenyl or —CH2-phenyl, and wherein the phenyl rings are optionally substituted by halogen, —C(O)-lower alkyl, —C(O)OH or —C(O)O-lower alkyl, or the aromatic rings are optionally substituted by heterocycloalkyl, OCH2-oxetan-3-yl or O-tetrahydropyran-4-yl, optionally substituted by lower alkyl;
• X is a bond, —NR′—, —CH2NH—, —CHR″—, —(CHR″)q—O—, —O—(CHR″)q— or —(CH2)2—;
• Y is a bond or —CH2—
• R′ is hydrogen or lower alkyl,
• R″ is hydrogen, lower alkyl, CF3, lower alkoxy,
• q is 0, 1, 2 or 3;
• or a pharmaceutically suitable acid addition salt thereof
• and a pharmaceutically acceptable carrier.