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AssigneeIntrexon Corporation
InventorsROBERT E. HORMANN, Inna SHULMAN, Eva RÖDEL, Rolf HILFIKER, Susan M. DEPAUL
Estimating the term…
The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject.
1-19. (canceled)
A method of regulating gene expression of a gene of interest in a host cell, the method comprising contacting said host cell with a composition comprising crystalline (R)-3.5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide Form III Form IV, Form V, Form VI Form VII, Form VIII, or Form IX, wherein:
22-23. (canceled)
A method of treating a cancer, a metabolic-related disorder, kidney disease, anemia, an autoimmune disorder, an ocular disorder, a blood disorder, a neurological disorder, a lung disorder, a rheumatologic disorder, or an infectious disease in a subject, the method comprising administering to said subject a composition comprising crystalline (R)-3.5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide Form III, Form IV, Form V, Form VI, Form VII, Form VIII, or Form IX, wherein:
(canceled)
27-31. (canceled)
A method of controlling insects, the method comprising contacting said insects or their habitat with an insecticidally effective amount of crystalline (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide Form III, Form IV, Form V, Form VI, Form VII, Form VIII, or Form IX, wherein:
35-38. (canceled)
Dependencies are inferred from the claim text.