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US 2020/0047175 A1Published application
Chromatography membranes formed by thiol-ene or thiol-yne click polymerization reactions
AssigneeNatrix Separations Inc.
InventorsAmro Ragheb, Gary Skarja
Life of this patent
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Abstract
Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
Claims18
1-14. (canceled)
A method of separating a substance from a fluid, comprising the steps of:
- contacting at a first flow rate a first fluid comprising a substance with a composite material comprising:
- a support member, comprising a plurality of pores extending through the support member;
- and
- a macroporous cross-linked gel, wherein the macroporous cross-linked gel comprises a polymer derived from a first monomer and a first cross-linker;
- wherein
- the macroporous cross-linked gel is located in the pores of the support member;
- the macropores of the macroporous cross-linked gel are smaller than the pores of the support member;
- the first monomer comprises two thiol functional groups;
- and
- the first cross-linker comprises (i) at least three carbon-carbon double bonds, (ii) at least two carbon-carbon triple bonds, or (iii) at least one carbon-carbon triple bond and at least one carbon-carbon double bond,
- thereby adsorbing or absorbing a portion of the substance onto the composite material.
8 more elements
Dependencies are inferred from the claim text.