Multi-Modal Ion-Exchange Membranes for Rapid Separations
AssigneeClemson University
InventorJINXIANG ZHOU
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Abstract
Ion exchange membranes (e.g., anion exchange membranes) and methods of using the membranes are described. The ion exchange membranes are multi-modal ion exchange membranes containing a plurality of multi-modal exchange ligands. The membranes can achieve high dynamic and equilibrium binding capacities at solution conductivities typical for production of biologics (e.g., greater than about 10 mS/cm) and can provide excellent binding at high flow rates. Systems incorporating the membranes can dramatically increase isolation and purification speeds. Membranes are disclosed for use in production of biologics.
Claims20
A method for forming a multi-modal ion exchange membrane comprising:
- grafting a polymer at a surface of a porous membrane, and
- covalently binding a ligand to the polymer, wherein upon the covalent binding, the polymer exhibits at least two modes of sorptive functionality to the membrane at the ligand, one of the modes being ionic.
A multi-modal ion exchange membrane comprising:
- a porous membrane substrate;
- a plurality of polymers grafted at a surface of the substrate;
- and
- a plurality of ligands bonded to each of the polymers, each ligand including multiple modes of sorptive functionality, at least one of the modes being ionic.
A method for separating a targeted species from a solution, the method comprising contacting a multi-modal ion exchange membrane with a solution, the solution comprising one or more targeted species, the solution having a solution conductivity of from about 0.5 millisiemans per centimeter to about 50 millisiemans per centimeter, the multi-modal ion exchange membrane comprising a porous membrane substrate, a plurality of polymers grafted at a surface of the substrate, and a plurality of ligands bonded to each of the polymers, each ligand including multiple modes of ion exchange functionality.
Dependencies are inferred from the claim text.