Non-invasive optogenetic stimulation method to regulate glucose metabolism in the liver and brown adipose tissue
AssigneeAlbert Einstein College of Medicine
InventorsYoung-Hwan Jo, Jae Hoon Jeong, Streamson Chua, JR.
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Abstract
Methods and devices are disclosed for non-invasive optogenetic stimulation of autonomic efferent fibers to regulate glucose metabolism in the liver and brown adipose tissue and to treat metabolic disorders.
Claims31
A non-invasive optogenetic method for modulating the activity of a metabolic organ in a subject, the method comprising applying light through the skin of the subject to activate a transmembrane ion channel channelrhodopsin virally-induced in autonomic efferent nerve fibers innervating the organ, where the light is applied in a wavelength, amount and duration effective to modulate activity of the organ in a subject.
A device for non-invasive optogenetic stimulation, the device comprising
- one or more surface-mounted-device light-emitting device (SMD-LED) modules,
- a Transistor-Transistor Logic (TTL) pulse generator, and
- a power supply,
- wherein the device is configured to be mounted on the skin of a subject.
Dependencies are inferred from the claim text.