Induced cell morphology electroporation
AssigneeVirginia Tech Intellectual Properties, Inc.
InventorsJILL W. IVEY, EDUARDO L. LATOUCHE, SCOTT S. VERBRIDGE, RAFAEL V. DAVALOS, GLENN J. LESSER, WALDEMAR DEBINSKI
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Abstract
Described herein are methods of electroporation that can include the steps of contacting a cell that is responsive to an EphA2 receptor ligand with an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to the cell. Also described herein are methods of treating cancer in a subject in need thereof, wherein the methods can include the steps of administering an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to a location on or within the subject.
Claims21
A method of electroporation comprising:
- contacting a cell responsive to an EphA2 receptor ligand with an amount of an EphA2 receptor ligand;
- and
- applying to the cell responsive to the EphA2 receptor ligand, a high-frequency irreversible electroporation (H-FIRE) pulse train.
A method of selectively ablating a cell responsive to an EphA2 receptor ligand or population thereof in a subject in need thereof, the method comprising:
- administering to the subject an amount of an EphA2 receptor ligand;
- and
- applying a high-frequency irreversible electroporation (H-FIRE) pulse train to a location on or within the subject.
-55. (canceled)
Dependencies are inferred from the claim text.