Apparatus, systems and methods for delivery of medication to the brain to treat neurological conditions

A method for intracranial delivery of medication to a brain of a patient in need thereof, the method comprising:

• positioning a diffusion chamber within a ventricle of the brain of the patient wherein the diffusion chamber conforms to the shape of ventricle without significant effect to the patient, the diffusion chamber configured to receive a solid form medication element comprising at least one drug;
• advancing a solid form medication element to the diffusion chamber;
• dissolving the solid form medication element within cerebrospinal fluid (CSF) within the chamber;
• and
• diffusing the drug from the diffusion chamber to CSF within the ventricle.

A method for intracranial delivery of medication to a target treatment location in a brain of a patient, the method comprising:

• positioning a delivery device to the target treatment location within a selected ventricle of the brain;
• the delivery device comprising a flexible delivery member and a diffusion chamber coupled to a distal end of the delivery member;
• wherein the flexible delivery member and diffusion chamber are delivered to and conform to the shape of ventricle without significant effect to the patient;
• wherein a proximal end of the flexible delivery member is coupled to a storage device for storing a plurality of solid form medication elements at a location outside of the brain, each of the solid form medication elements comprising a therapeutically effective dose of a drug;
• individually advancing a first dose of medication in the form of one of the solid form medication elements from the storage device and through the flexible delivery member to the diffusion chamber;
• dissolving the solid form medication element within cerebrospinal fluid (CSF) within the chamber at the target treatment location;
• and
• diffusing the drug from the diffusion chamber to CSF at the target treatment location within the ventricle.

A method for treatment or prevention of epilepsy in a patient, the method comprising:

• positioning a delivery device to the target treatment location within a selected ventricle of a brain of the patient;
• the delivery device comprising a flexible delivery member and a diffusion chamber coupled to a distal end of the delivery member;
• wherein the flexible delivery member and diffusion chamber are delivered to and conform to the shape of ventricle without significant effect to the patient;
• wherein a proximal end of the flexible delivery member is coupled to a storage device for storing a plurality of solid form medication elements at a location outside of the brain, each of the solid form medication elements comprising a therapeutically effective dose of a drug;
• individually advancing a first dose of medication in the form of one of the solid form medication elements from the storage device and through the flexible delivery member to the diffusion chamber;
• dissolving the solid form medication element within cerebrospinal fluid (CSF) within the chamber at the target treatment location;
• diffusing the drug from the diffusion chamber to CSF at the target treatment location within the ventricle;
• and
• blocking an evoked or spontaneous epileptic neural activity via the drug-infused CSF.