Systems and methods for delivery of a therapeutic agent
AssigneeThe Foundry, LLC
InventorsMark E. Deem, Hanson Gifford
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Abstract
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
Claims30
A method of treating a nasal condition of a patient comprising:
- positioning a distal portion of a treatment device proximate to target tissue in a nasopharyngeal passage of a patient;
- and
- administering therapy to the target tissue with the treatment device so as to disrupt neural activity such that mucus secretion is reduced in the nasopharyngeal passage;
- wherein administering therapy comprises at least one of delivering energy to the target tissue and changing the temperature of the target tissue.
A method of treating a nasal condition of a patient comprising:
- positioning a distal portion of a treatment device proximate to target tissue in a nasopharyngeal passage of a patient;
- and
- administering therapy to the target tissue with the treatment device to alter nasopharyngeal cells such that congestion in the nasopharyngeal passage is reduced;
- wherein administering therapy comprises delivering energy to the target tissue.
Dependencies are inferred from the claim text.