Cerebrospinal fluid purification system
AssigneeNeurofluidics, Inc.
InventorsSHIVANAND LAD, WILLIAM C. MOBLEY, KAROLY NIKOLICH, THOMAS SAUL
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Abstract
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
Claims20
A method for ameliorating a symptom of multiple sclerosis in a patient, said method comprising:
- selecting a patient having a symptom of multiple sclerosis;
- removing cerebrospinal fluid from a first location in a lumbar cerebrospinal fluid space of the patient;
- removing a causative agent from the removed cerebrospinal fluid, thereby conditioning the cerebrospinal fluid;
- and
- returning the conditioned cerebrospinal fluid to the patient at a second location in a cervical cerebrospinal fluid space, a thoracic cerebrospinal fluid space, or a ventricle of the patient, wherein the cerebrospinal fluid is returned to the patient at substantially the same flow rate at which it is removed;
- wherein the removing and returning steps are performed concurrently using one or more catheters, each catheter comprising one or more lumens.
A method for ameliorating a symptom of Guillain Barre Syndrome in a patient, said method comprising:
- selecting a patient having a symptom of Guillain Barre Syndrome;
- removing cerebrospinal fluid from a first location in a lumbar cerebrospinal fluid space of the patient;
- removing a causative agent from the removed cerebrospinal fluid, thereby conditioning the cerebrospinal fluid;
- and
- returning the conditioned cerebrospinal fluid to the patient at a second location in a cervical cerebrospinal fluid space, a thoracic cerebrospinal fluid space, or a ventricle of the patient, wherein the cerebrospinal fluid is returned to the patient at substantially the same flow rate at which it is removed;
- wherein the removing and returning steps are performed concurrently using one or more catheters, each catheter comprising one or more lumens.
Dependencies are inferred from the claim text.