Compositions and devices to administer pharmaceutical compositions nasally
AssigneeBoard of Regents, The University of Texas System
InventorsHugh D.C. SMYTH, Robert O. WILLIAMS, III, Zachary WARNKEN, Yang LU
Life of this patent
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Abstract
Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.
Claims96
An apparatus for nasal administration of a pharmaceutical composition, the apparatus comprising:
- a reservoir;
- a conduit in fluid communication with the reservoir;
- an actuator configured to transfer a pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit;
- and
- an anatomic positioning device configured to position the conduit in a nasal cavity of a user.
A method of developing individualized administration of a pharmaceutical composition to a person, the method comprising:
- obtaining one or more images of a nasal cavity of the person;
- creating a three-dimensional model of the nasal cavity;
- and
- determining person-specific parameters for a device configured to administer the pharmaceutical composition to the person, wherein the person-specific parameters are based on the three-dimensional model of the nasal cavity.
A pharmaceutical composition comprising:
- (A) a therapeutic agent;
- and
- (B) a pharmaceutical excipient, wherein:
- the pharmaceutical composition is formulated for administration intranasally for delivery to the brain;
- and
- the pharmaceutical composition is formulated as a solid dispersion.
A pharmaceutical composition comprising:
- (A) a therapeutic agent;
- and
- (B) a pharmaceutical excipient, wherein:
- the pharmaceutical composition is formulated for administration intranasally for delivery to the brain;
- and
- the pharmaceutical composition is formulated as a foam.
A method of delivering a pharmaceutical composition to a subject, the method comprising:
- inserting an apparatus into a nasal cavity of the subject, wherein the apparatus is anatomically modeled after the nasal cavity of the subject;
- and
- emitting the pharmaceutical composition from the apparatus into the nasal cavity of the subject.
Dependencies are inferred from the claim text.