Compositions for tissue hemostasis, repair and reconstruction

A multi-putty settable surgical adhesive composition comprising two separate, individual reactive putties, a first putty comprising particles from a ground lyophilized sponge containing a polyanionic polymer salt and a second putty comprising particles from a ground lyophilized sponge containing a polycationic polymer salt wherein, when the two putties are combined together with a polyvalent metallic salt and, when wetted with an aqueous solution, form an adhesive that cures into a hardened state.

A multi-putty settable surgical adhesive composition comprising two separate, individual reactive putties, a first putty comprising a mixture of polyethylene glycol (PEG) monostearate and PEG containing tetracalcium phosphate, phosphoserine and dry buffer-producing powder and a second putty comprising a mixture of PEG monostearate and PEG containing fibrous or powdered absorbable polymer containing backbone ester groups or fibrous or powdered nonabsorbable polymer containing backbone ester groups.

A multi-putty settable surgical adhesive composition comprising two separate, individual reactive putties, a first putty being acidic and comprising an alkylene oxide glycol mono-fatty acid ester, an alkylene oxide glycol, an acidic phosphate salt, an acidic pH buffering agent, an optional humectant and an optional poloxamer and a second putty being basic and comprising an alkylene oxide glycol mono fatty acid ester, an alkylene oxide glycol, a basic calcium phosphate salt, a surfactant and, optionally, osteoconductive and/or osteoinductive agents.

A multi-putty settable surgical adhesive composition comprising two separate, individual reactive putties, a first putty comprising one or more basic calcium phosphate salts, a polyol, a polyol-terminated polyurethane prepolymer and an optional osteoactive ceramic and a second putty comprising an acidic calcium phosphate salt, a polyisocyanate, an isocyanate-terminated prepolymer, and an optional osteoactive ceramic.

A multi-putty settable surgical adhesive composition comprising two separate, individual reactive putties, a first putty comprising an aliphatic or aromatic polyisocyanate, an osteoactive calcium phosphate, magnesium oxide, dibasic potassium phosphate, tetracalcium phosphate and a viscous isocyanate-terminated polyurethane prepolymer, and a second putty comprising phosphoserine, one or more polyols, BMP and/or DBM, optionally N-methyl pyrrolidone, an osteoactive calcium phosphate and a viscous, hydroxyl-terminated polyurethane prepolymer.

A multi-putty settable surgical composition comprising two separate, individual reactive putties, a first putty comprising powdered monobasic potassium phosphate and powdered calcined magnesium oxide dispersed in an anhydrous mixture of PEG diacetate and monoacetyl PEG stearate, optionally containing an osteoactive calcium phosphate;

• and a second putty comprising a dispersion of powdered beta-tricalcium phosphate and powdered sucrose in an anhydrous mixture of PEG diacetate and monoacetyl PEG stearate, optionally containing an osteoactive ceramic.

A multi-putty settable surgical composition comprising two separate, individual reactive putties, a first putty comprising an aliphatic and/or aromatic polyglycidyl epoxy resin of sufficient molecular weight to provide a putty-like consistency and a second putty comprising an optional thickener and a tertiary amine catalyst to form a homopolymer through catalytic homopolymerization.

A multi-putty settable surgical composition comprising two separate, individual reactive putties, a first putty comprising an aliphatic and/or aromatic polyglycidyl epoxy resin of sufficient molecular weight to provide a putty-like consistency and a second putty containing an optional thickener and a polyfunctional primary and/or secondary amine, polyfunctional anhydride, polyfunctional phenol or polyfunctional thiol.

A multi-putty settable surgical composition comprising two separate individual reactive putties, a first putty comprising liquid acrylate and/or methacrylate monomers and acrylate and/or methacrylate polymers and a second putty comprising a free radical catalyst precursor or an ionic catalyst precursor in a biocompatible organic solvent.

A multi-putty settable surgical composition comprising two separate individual reactive putties, a first putty comprising an incubated mixture of a polyol and freeze-dried clotted blood plasma and a second putty comprising a polyisocyanate terminated prepolymer.

A multi-putty settable surgical adhesive composition comprising two separate, individual reactive putties, one putty comprising tetracalcium phosphate powder in an aqueous vehicle and the second putty comprising phosphoserine and polyester in a non-aqueous vehicle.