Porphyrin modified telodendrimers
AssigneeThe Regents of the University of California
InventorsKit S. LAM, Yuanpei LI, Chong-Xian PAN
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Abstract
The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.
Claims29
-19. (canceled)
A nanocarrier having an interior and an exterior, the nanocarrier comprising a plurality of first conjugates wherein each conjugate comprises
- a polyethylene glycol (PEG) polymer;
- at least two amphiphilic compounds having both a hydrophilic face and a hydrophobic face;
- at least one porphyrin;
- optionally at least two crosslinking groups;
- and
- a dendritic polymer covalently attached to the PEG, the amphiphilic compounds, the porphyrin and the crosslinking groups,
- wherein each conjugate self-assembles in an aqueous solvent to form the nanocarrier such that a hydrophobic pocket is formed in the interior of the nanocarrier by the orientation of the hydrophobic face of each amphiphilic compound towards each other, wherein the PEG of each conjugate self-assembles on the exterior of the nanocarrier.
-34. (canceled)
Dependencies are inferred from the claim text.