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US 2020/0046838 A1Published application
Lipids for delivery of active agents
AssigneeAcuitas Therapeutics, Inc.
InventorsSteven M. Ansell, Xinyao Du
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Abstract
Compounds are provided having the following structure: Formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, G1, G2 and n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
Claims45
A compound having the following structure (I):
- or a pharmaceutically acceptable salt, prodrug or stereoisomer thereof, wherein:
- G1 is —OH, —NR3R4, —(C═O)NR5 or —NR3(C═O)R5;
- G2 is —CH2— or —(C═O)—;
- R is, at each occurrence, independently H or OH;
- R1 and R2 are each independently optionally substituted branched, saturated or unsaturated C12-C36 alkyl;
- R3 and R4 are each independently H or optionally substituted straight or branched, saturated or unsaturated C1-C6 alkyl;
- R5 is optionally substituted straight or branched, saturated or unsaturated C1-C6 alkyl;
- and
- n is an integer from 2 to 6.
6 more elements
Dependencies are inferred from the claim text.