Systems, Methods, and Compositions For Cross-Linking Treatments of an Eye

A system for applying treatment to a cornea of an eye, comprising:

• a composition including:
• a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light, the cross-linking agent including at least 0.1% riboflavin;
• at least 0.25 mM of an iron additive;
• and
• citrate buffer;
• a light source configured to emit the photo-activating light;
• one or more optical elements configured to direct the photo-activating light from the light source to an area of the cornea;
• and
• a controller configured to control at least one of the light source or the one or more optical elements to deliver a dose of the photo-activating light to the area of the cornea to generate cross-linking activity based on an application of the composition to the cornea.