Nanoemulsion comprising imidazoquinoline-based material and use thereof
AssigneeDandi Bioscience Inc
InventorsYong Taik LIM, Sun-Young KIM
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Abstract
The present invention relates to a nanoemulsion comprising an oil layer comprising imidazoquinoline-based toll-like receptor 7 or 8 agonist and oil, and a use thereof as an adjuvant and vaccine. According to the present invention, it is possible to provide a vaccine adjuvant in the form of a nanoemulsion that can dissolve an insoluble imidazoquinoline-based material in oil using a dispersion helper and disperse the oil solution easily and reproducibly in a water-soluble manner.
Claims17
A nanoemulsion comprising an oil layer comprising an imidazoquinoline-based toll-like receptor 7 or 8 agonist and oil.
A method of preparing a nanoemulsion, the method comprising:
- a) preparing an oil solution by dissolving an imidazoquinoline-based toll-like receptor 7 or 8 agonist in oil;
- b) mixing the oil solution with one or more selected from the group consisting of a surfactant and an immunostimulatory agent;
- c) dispersing the mixed solution obtained in process b) in an aqueous solution.
Dependencies are inferred from the claim text.