Toothpaste for Delivery of Allergens to Oral Mucosa
AssigneeAllovate, LLC
InventorsMichael Nelson, Erick Berglund
Life of this patent
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Abstract
Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (OMIT) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen/extracts of allergens, and optionally compounding means and/or specialized toothbrushes are provided. Toothpastes suitable and effective for OMIT and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes and kits of the invention are also disclosed.
Claims21
1-13. (canceled)
A method of formulating a toothpaste suitable for oral mucosal therapy, the method comprising:
- providing a first volume of solution comprising an allergen or allergen extract and a concentration of sugar alcohol;
- formulating a second volume of pro-toothpaste comprising a reduced concentration of vehicle and an increased concentration of thickener when compared to a conventional toothpaste, the vehicle comprising a sugar alcohol corresponding to the sugar alcohol of the first volume in a concentration substantially corresponding to the concentration of sugar alcohol of the first volume, the first and second volumes being combinable in a ratio such that a concentration of sugar alcohol in the combined volume is between about 40% and 55% by volume, and mixing the first volume and second volume in the ratio.
20-30. (canceled)
A method of formulating a toothpaste suitable for oral mucosal therapy, the method comprising:
- pulverizing a source allergen material;
- incubating the pulverized source allergen material in an aqueous medium to at least partially solubilize allergenic proteins, thereby providing a crude allergen extract;
- suspending the crude allergen extract in a concentration of sugar alcohol to provide a first volume;
- formulating a second volume of pro-toothpaste comprising a vehicle and a thickener, wherein the vehicle comprises a sugar alcohol corresponding to the sugar alcohol of the first volume in a concentration corresponding to the concentration of sugar alcohol of the first volume, the first and second volumes being combinable in a ratio such that a concentration of sugar alcohol in the combined volume is between about 40% and 60% by volume;
- and
- mixing the first volume and second volume in the ratio,
- wherein the sugar alcohol is glycerol.
Dependencies are inferred from the claim text.