A virus like particle of hepatitis b virus pre-s protein
AssigneesGeorgia State University Research Foundation, Inc., Peking University
InventorMing Luo
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Abstract
As disclosed herein, the preS antigen on infectious hepatitis B virus (HBV) particles can provide B and T ceil epitopes that promote the humoral and cellular responses and enhance the seroprotection rate by overcoming non-responsiveness to the S antigen-only vaccines. Therefore, compositions and methods are disclosed using the preS antigen to develop vaccines and immune therapies for treating or preventing hepatitis B infection, in particular, virus-like particles (VLPs) are disclosed that contain the preS antigen on its surface. These VLPs can be used alone or in combination with vaccines containing the hepatitis B surface antigen (HBsAg) to vaccinate subjects against HBV as well as to activate T ceils for adoptive T cell therapy to eradicate HBV infected hapatocytes.
Claims20
A fusion protein comprising a hepatitis B preS antigen fused at the N-terminus of a transmembrane domain and optional cytoplasmic tail of a viral envelope protein.
Dependencies are inferred from the claim text.