Compositions and Methods for Antigen-Specific Tolerance
AssigneesNorthwestern University, Myelin Repair Foundation, Inc.
InventorsStephen D. Miller, Michael A. Pleiss, Daniel R. Getts, Aaron Martin
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Abstract
The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject.
Claims17
A method of inducing antigen-specific tolerance in a subject suffering from or at risk of an autoimmune disease, transplant rejection, or allergy comprising intravenously administering a composition to said subject, wherein said composition comprises an apoptotic body surrogate and a plurality of immunodominant epitopes associated with one or more antigens suspected to cause said autoimmune disease, transplant rejection, or allergy.
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Dependencies are inferred from the claim text.