Compositions and methods using il-8 to improve milk production and reproductive health in mammals
AssigneeCornell University
InventorRodrigo Carvalho BICALHO
Life of this patent
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Abstract
The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of IL-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased. In another aspect the disclosure includes prophylaxis and/or therapy of uterine conditions by administering IL-8 to a female mammal.
Claims15
A method for increasing milk production and/or increasing fat content of milk produced by a female mammal, the method comprising administering to the female mammal within twenty weeks post parturition an effective amount of Interleukin-8 (IL-8) such that:
- i) milk produced by the female is increased subsequent to the administration relative to a control;
- and/or
- ii) the amount of milk fat in milk produced mammal is increased relative to a control.
Milk having an increased fat content relative to a reference, wherein the milk is produced by administering IL-8 to a female mammal and obtaining the milk from the mammal subsequent to administering the IL-8.
A kit for i) improving health of a female mammal, and/or ii) increasing milk production and/or fat content of milk produced by the mammal, the kit comprising IL-8 in one or more sealed containers, a delivery device, and instructions for introducing IL-8 to a female mammal to obtain i) or ii).
An article of manufacture comprising IL-8 in a sealed container, packaging, and printed information, the printed information identifying IL-8 as a content of the package and providing an indication that the IL-8 is to be used for improving health of a female mammal, and/or ii) increasing milk production and/or fat content of milk produced by the mammal.
Dependencies are inferred from the claim text.