Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing
AssigneeTechnion Research & Development Foundation Limited
InventorsYaron FUCHS, Yahav YOSEFZON, Despina SOTERIOU
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Abstract
Provided are methods of selecting a treatment for a cancer in a subject in need thereof, by analyzing activity of Yes associated protein 1 (YAP) in cancer cells of the subject, and methods of treating cancer using a therapeutically effective amount of an caspase-3 inhibitor. Also provided are methods of improving wound healing by administering a wound healing effective amount of a caspase-3 activator.
Claims16
A method of selecting a treatment for a cancer in a subject in need thereof, the method comprising analyzing activity of Yes associated protein 1 (YAP) in cancer cells of the subject, wherein an up-regulation in activity of said YAP above a predetermined level as compared to an activity of said YAP in a matching non-cancerous tissue classifies said subject suitable for treatment of cancer with a caspase 3 inhibitor.
A method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a caspase-3 inhibitor, wherein the cancer cells of said cancer exhibit up-regulation in activity of Yes associated protein (YAP) above a predetermined level as compared to an activity of said YAP in a matching non-cancerous tissue.
A method of treating wound healing in a subject, comprising administering to the subject in a local manner an effective amount of a wound healing caspase-3 activator, wherein said effective amount of said caspase-3 is capable of increasing activity of Yes associated protein 1 (YAP) above a predetermined level as compared to a wounded area of a subject non-treated by said caspase-3 activator.
Dependencies are inferred from the claim text.