Compositions and methods for treatment of intestinal inflammation and colon cancer
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorHuang-Ge Zhang
Life of this patent
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Abstract
Methods for treating intestinal inflammation and/or colon cancer include administering an amount of a broccoli-derived nanoparticle to a subject in need thereof. Pharmaceutical compositions comprising broccoli-derived nanoparticles are also provided. Further provided are methods for screening for a compound useful for treating a colon cancer that include the steps of contacting a provided intestinal epithelial cell with a test compound and measuring an amount of expression of COP9 signalsome subunit 8 (CSN8) in the intestinal epithelial cell to thereby identify the test compound as useful for treating colon cancer.
Claims20
A method of treating intestinal inflammation, comprising administering to a subject in need thereof an effective amount of a broccoli-derived nanoparticle.
A method of treating a colon cancer, comprising administering to a subject in need thereof an effective amount of a broccoli-derived nanoparticle.
A pharmaceutical composition, comprising a broccoli-derived nanoparticle and a pharmaceutically-acceptable vehicle, carrier, or excipient.
(canceled)
Dependencies are inferred from the claim text.