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US 2020/0046785 A1Published application
P53-targeting vaccines and pd-1 pathway inhibitors and methods of use thereof
AssigneeCity of Hope
InventorDon J. DIAMOND
Life of this patent
Estimating the term…
Abstract
The disclosure provides, inter alia, methods and materials involved in treating cancer using a p53 vaccine in combination with a PD-1 pathway inhibitor.
Claims21
1-160. (canceled)
A method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of a p53-targeting vaccine and an effective amount of a PD-1 pathway inhibitor to treat the cancer.
A method of treating cancer in a human in need thereof, the method comprising administering to the human:
- (i) from about 1.9×108 pfu to about 6.5×108 pfu of a modified vaccinia Ankara virus vaccine that expresses a nucleic acid sequence having at least 95% sequence identity to SEQ ID NO:1;
- and (ii) from about 100 mg to about 300 mg of pembrolizumab.
Dependencies are inferred from the claim text.