Fasl-engineered biomaterials with immunomodulatory function
AssigneesUniversity of Louisville Research Foundation, Inc., Georgia Tech Research Corporation
InventorsHaval SHIRWAN, Andres J. GARCIA, Esma S. YOLCU, Hong ZHAO, Devon HEADEN
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Abstract
Described herein are FasL-engineered biomaterials, as well as methods of making and using such FasL-engineered biomaterials, such as for immunomodulation, such as for inducing immunosuppression and specific immune tolerance, such as for preventing or reducing the risks of rejection of cellular or tissue grafts and/or the treatment of autoimmune disorders such as Type I diabetes. In specific embodiments, the FasL-engineered biomaterials are biotinylated microgels bound to SA-FasL.
Claims37
A biomaterial engineered to display a FasL protein.
A method of inducing immune tolerance in a subject in need thereof, comprising administering to the subject a biomaterial engineered to display a FasL protein in an amount effective to induce immune tolerance.
Dependencies are inferred from the claim text.