Composition for preventing or treating bone diseases which has excellent bone regeneration effect
OwnerJae Jun SONG, Ho Seok SONG +1inventors
InventorsJae Jun SONG, Ho Seok SONG, Yoon Young GO
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Abstract
The present invention relates to a composition for preventing or treating bone diseases, comprising a BMP-2-encoding gene and HSV-tk-encoding gene, and as an active ingredient a stem cell into which a dual kill switch expression vector in which an HGPRT-encoded gene is knocked out is introduced or a cell differentiated from the stem cell, wherein the bone regeneration effect is realized by a BMP-2 growth factor and at the same time, apoptosis may also be dually controlled by the dual kill switch.
Claims9
A composition for preventing or treating a bone disease, the composition comprising:
- a BMP-2-encoding gene;
- an HSV-tk-encoding gene;
- and
- a stem cell into which a dual kill switch expression vector in which an HGPRT-encoding gene is knocked out is introduced, or a cell differentiated from the stem cell, as an active ingredient.
A method of preparing a composition for preventing or treating a bone disease, the method comprising:
- preparing a vector comprising a BMP-2-encoding gene and an HSV-tk-encoding gene;
- knocking out an HGPRT-encoding gene in the vector;
- and
- introducing the vector into a stem cell or a cell differentiated from the stem cell.
Dependencies are inferred from the claim text.