Double negative t cells and pd-1 blockade for the treatment of cancer
AssigneeUniversity Health Network
InventorsLi Zhang, Dalam Ly, Linan Fang
Life of this patent
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Abstract
Methods for the treatment of cancer using double negative T cells (DNTs) and a PD-1 or PD-L1 inhibitor are described. Tumors treated with DNTs and a PD-1 inhibitor exhibited increased DNT cell infiltration and increased cytotoxicity towards non-small cell lung cancer (NSCLC) cells. Also described are compositions and kits comprising DNTs and a PD-1 or PD-L1 inhibitor and their use for the treatment of cancer.
Claims20
A method of treating cancer in a subject in need thereof, the method comprising administering to the subject double negative T cells (DNTs) and a PD-1 or PD-L1 inhibitor.
A method of reducing the growth or proliferation of a tumor, the method comprising contacting the tumor with double negative T cells (DNTs) and a PD-1 or PD-L1 inhibitor.
A composition comprising double negative T cells (DNTs) and a PD1 or PD-L1 inhibitor.
Dependencies are inferred from the claim text.