Oral cholestyramine formulation and use thereof
OwnerPer-Göran Gillberg, Nils Ove Gustafsson +2inventors
InventorsPer-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
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Abstract
The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are coated with a diffusion-controlled inner coating and an enteric outer coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.
Claims25
An oral formulation for targeted delivery of cholestyramine to the colon, comprising:
- a) a plurality of extruded and spheronized pellets, each extruded and spheronized pellet comprising at least about 70% w/w cholestyramine and at least about 5% w/w of an acrylate copolymer;
- b) a diffusion-controlled inner coating surrounding each extruded and spheronized pellet;
- and
- c) an enteric outer coating.
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A method for treating bile acid malabsorption in a patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of an oral formulation comprising:
- a) a plurality of extruded and spheronized pellets, each extruded and spheronized pellet comprising cholestyramine and at least about 5% w/w of an acrylate copolymer;
- b) a diffusion-controlled inner coating surrounding each extruded and spheronized pellet;
- and
- c) an enteric outer coating.
-31. (canceled)
Dependencies are inferred from the claim text.