Cholestyramine pellets, oral cholestyramine formulations, and uses thereof
OwnerPer-Göran Gillberg, Nils Ove Gustafsson +2inventors
InventorsPer-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
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Abstract
The invention relates to a population of pellets, each pellet comprising cholestyramine and at least about 5% w/w of an acrylate copolymer. The invention also relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets and wherein said pellets are coated with a colon release coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.
Claims24
A population of extruded and spheronized pellets, each extruded and spheronized pellet comprising at least about 70% w/w cholestyramine and at least about 5% w/w of an acrylate copolymer.
(canceled)
(canceled)
An oral formulation for targeted delivery of cholestyramine to the colon, comprising:
- a) a plurality of extruded and spheronized pellets, each extruded and spheronized pellet comprising at least about 70% w/w cholestyramine and at least about 5% w/w of an acrylate copolymer;
- and
- b) a colon release coating surrounding each extruded and spheronized pellet.
-32. (canceled)
A method for treating bile acid malabsorption in a patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of an oral formulation comprising:
- a) a plurality of extruded and spheronized pellets, each extruded and spheronized pellet comprising at least about 70% w/w cholestyramine and at least about 5% w/w of an acrylate copolymer;
- and
- b) a colon release coating surrounding each extruded and spheronized pellet.
-45. (canceled)
Dependencies are inferred from the claim text.