Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients
AssigneeThe Brigham and Women S Hospital, Inc.
InventorsJeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Abstract
This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.
Claims29
A dehydrated acid-pretreated composition comprising particles comprising one or more aluminum cross-linked sulfated agents, wherein the composition has an aluminum content of less than 15.5% and can form a paste following contact with an aqueous liquid in the absence of acid.
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A method of making a stable, sulfated agent hydratable composition, the method comprising:
- mixing a sulfated agent with an acid solution to form a viscous precipitate;
- and
- dehydrating the viscous precipitate by
- (i) mixing the viscous precipitate with a sufficient amount of a water-miscible solvent for a time sufficient to obtain a particle suspension, and removing particles from the suspension to obtain a stable, sulfated agent hydratable composition of particles;
- or
- (ii) applying microwave energy for a time sufficient to obtain a stable, sulfated agent hydratable composition of particles.
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Dependencies are inferred from the claim text.