Compounds and methods for treating neurological and cardiovascular conditions

A method of treating a brain or central nervous system (CNS) injury or condition comprising administering to a patient in need thereof an effective amount of a compound selected from:

• or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable composition thereof;
• wherein the brain or CNS injury or condition is selected from radiation damage, migraine headache, ischemic stroke, hemorrhagic stroke, subarachnoid hemorrhage, cerebral vasospasm, or transient ischemic attacks (TIA).

A method of treating a neurodegenerative condition, or a condition mediated by a brain injury or a neurodegenerative condition, comprising administering to a patient in need thereof an effective amount of a compound selected from:

• or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable composition thereof.

A method of treating a heart or cardiovascular disease, comprising administering to a patient in need thereof an effective amount of a compound selected from:

• or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable composition thereof;
• wherein the heart or cardiovascular disease is selected from heart disease, cardiovascular disease, cardiac ischemia, arrhythmia, cardiac ischemia, or myocardial infarction.

A method of treating a disease or condition, comprising administering to a patient in need thereof an effective amount of a compound selected from:

• or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable composition thereof;
• wherein the disease or condition is selected from an autoimmune disease or condition, glaucoma, an otic disorder, progressive hearing loss, tinnitus, collateral brain damage associated with radiation cancer therapy or migraine treatment, epilepsy, pain control, pain mediated by the CNS, neuropathic pain, inflammatory pain, or acute pain.

A method of increasing cardioprotection or regeneration of damaged heart tissue in a patient who has suffered a cardiac ischemia or myocardial infarction, comprising administering to a patient in need thereof an effective amount of a compound selected from:

• or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable composition thereof.

A method of treating a disease or condition, comprising administering to a patient in need thereof an effective amount of 2-methylthioadenosine:

• or a pharmaceutically acceptable salt thereof or pharmaceutically acceptable composition thereof;
• wherein the disease or condition is selected from a traumatic brain injury (TBI), stroke, a heart or cardiovascular disease, a neurodegenerative condition, a condition mediated by a brain injury or neurodegenerative condition, radiation damage, migraine headache, an autoimmune disease or condition, glaucoma, an otic disorder, progressive hearing loss, tinnitus, collateral brain damage associated with radiation cancer therapy or migraine treatment, epilepsy, pain control, pain mediated by the CNS, neuropathic pain, inflammatory pain, or acute pain.

A method of increasing neuroprotection or neurorestoration in a patient who has suffered a TBI or stroke, comprising administering to a patient in need thereof an effective amount of 2-methylthioadenosine:

• or a pharmaceutically acceptable salt thereof or pharmaceutically acceptable composition thereof.

A method of increasing cardioprotection or regeneration of damaged heart tissue in a patient who has suffered a cardiac ischemia or myocardial infarction, comprising administering to a patient in need thereof an effective amount of 2-methylthioadenosine:

• or a pharmaceutically acceptable salt thereof or pharmaceutically acceptable composition thereof.