Sialylation-increasing therapies for diseases associated with oxidative stress
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Servic
InventorsMarjan Huizing, May C. Malicdan, Nuria Carrillo
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Abstract
Methods are disclosed for treating a subject with a vascular or cardiac disorder associated with oxidative stress. Methods are disclosed for treating a subject with GNE myopathy that has impaired cardiac function. These methods include administering to the subject a therapeutically effective amount of a sialic acid precursor, sialic acid, or one or more sialylated compounds, mannosamine, N-acetyl mannosamine or a derivative thereof. In other embodiments, methods are disclosed for detecting a disorder associated with oxidative stress.
Claims23
A method for treating a subject with a cardiovascular disorder associated with oxidative stress, comprising
- selecting a subject that has the cardiovascular disorder associated with oxidative stress and does not have a GNE myopathy;
- and
- administering to the subject a therapeutically effective amount of a mannosamine, N-acetyl mannosamine or a derivative thereof, wherein the derivative is:
- wherein:
- R1, R3, R4, or R5 is hydrogen, lower alkanoyl, carboxylate or lower alkyl;
- and R2 is lower alkyl, lower alkanoylalkyl, or lower alkyl alkanoyloxy, thereby treating the cardiovascular disorder in the subject.
A method for treating impaired cardiac function in a subject that does not have a GNE myopathy, comprising
- selecting a subject that has the impaired cardiac function and does not have the GNE myopathy;
- and
- administering to the subject a therapeutically effective amount of mannosamine, N-acetyl mannosamine or a derivative thereof, wherein the derivative is:
- wherein:
- R1, R3, R4, or R5 is hydrogen, lower alkanoyl, carboxylate or lower alkyl;
- and R2 is lower alkyl, lower alkanoylalkyl, or lower alkyl alkanoyloxy, thereby improving cardiac function in the subject.
Dependencies are inferred from the claim text.