Fatty acid acetylated salicylates and their uses

A method of treating inflammation that is associated with a neurodegenerative disorder selected from the group consisting of Huntington's Disease, infectious meningitis, encephalomyelitis, Parkinson's disease, and encephalitis, comprising administering to a patient in need thereof an effective amount of a compound of Formula I:

• or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof,
• wherein:
• R1, R2, R3, and R4 are each independently selected from the group consisting of H, Cl, F, CN, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —NH(C(O)C1-C3 alkyl), —N(C(O)C1-C3 alkyl)2, —C(O)H, —C(O)C1-C3 alkyl, —C(O)OC1-C3 alkyl, —C(O)NH2, —C(O)NH(C1-C3 alkyl), —C(O)N(C1-C3 alkyl)2, —O—C1-C3 alkyl:
• W1 is NH and W2 is selected from null, O, or NH;
• - - - - - represents an optional bond that when present requires that Q is null;
• a and c are each independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
• b is H, CH3, C(O)OH, or O—Z;
• d is H or C(O)OH;
• each n, o, p, and q is independently 0 or 1;
• each Z is H or
• with the proviso that there is at least one
• in the compound;
• each r is independently 2 or 3;
• each s is independently 5 or 6;
• each t is independently 0 or 1;
• Q is null, C(0)CH3, Z,
• e is H or any one of the side chains of the naturally occurring amino acids;
• W3 is null, O, or —N(R)—;
• R is H or C1-C3 alkyl;
• and
• T is H, C(O)CH3, or Z.

A method of treating inflammation that is associated with a muscle wasting disorder selected from the group consisting of dermatomyositis, inclusion body myositis, polymyositis, and cachexia, comprising administering to a patient in need thereof an effective amount of a compound of Formula I:

• or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof,
• wherein:
• R1, R2, R3, and R4 are each independently selected from the group consisting of H, Cl, F, CN, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —NH(C(O)C1-C3 alkyl), —N(C(O)C1-C3 alkyl)2, —C(O)H, —C(O)C1-C3 alkyl, —C(O)OC1-C3 alkyl, —C(O)NH2, —C(O)NH(C1-C3 alkyl), —C(O)N(C1-C3 alkyl)2, —O—C1-C3 alkyl;
• W1 is NH and W2 is selected from null, O, or NH;
• - - - - - represents an optional bond that when present requires that Q is null;
• a and c are each independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
• b is H, CH3, C(O)OH, or O—Z;
• d is H or C(O)OH;
• each n, o, p, and q is independently 0 or 1;
• each Z is H or
• with the proviso that there is at least one
• in the compound;
• each r is independently 2 or 3;
• each s is independently 5 or 6;
• each t is independently 0 or 1;
• Q is null, C(O)CH3, Z,
• e is H or any one of the side chains of the naturally occurring amino acids;
• W3 is null, O, or —N(R)—;
• R is H or C1-C3 alkyl;
• and
• T is H, C(O)CH3, or Z.