Methods for treating cancer, and compositions therefor
AssigneeNotable Labs, Inc.
InventorsKamran Ali, Nina Myers, Christos Gekas, Diane Heiser, Stephen Western, Marianne Santaguida, Matt De Silva
Life of this patent
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Abstract
Provided herein are methods for treating proliferative diseases, such as cancer, via novel priming-eligible targets; and compositions therefor.
Claims46
1-4. (canceled)
A kit comprising one or more priming agents selected from any combination of one or more of Dexamethasone, Tretinoin, Calcitrol, and Panobinostat.
A method for treating a proliferative disease in a subject in need thereof, comprising:
- a. priming the subject with one or more priming agents to increase the level of a specified target;
- and
- b. administering to the subject an effective amount of a therapeutic agent that binds to the specified target.
A method for identifying druggable therapeutic targets, comprising:
- a. contacting a test-cancerous-cell, and a non-cancerous-control-cell, with one or more priming agents;
- b. assaying marker expression on both the test-cancerous-cell and the non-cancerous-control-cell in response to the priming agent, and further assaying surface marker expression on a control-cancerous-cell that was not contacted with priming agents;
- and
- c. identifying as a candidate therapeutic target any markers that have increased expression in the test-cancer-cell compared to both the control-cancerous-cell and the non-cancerous-control-cell.
A method for identifying druggable targets, comprising:
- a. contacting a test-cancerous-cell, and a non-cancerous-control-cell, with one or more priming agents;
- and
- b. assaying surface marker expression on both the test-cancerous-cell and the non-cancerous-control-cell in response to the priming agent, and further assaying surface marker expression on a control-cancerous-cell that was not contacted with priming agents;
- wherein increased surface marker expression of a particular target on the test-cancerous-cell compared to both the control-cancerous-cell and the non-cancerous-control-cell, identifies a druggable target.
A method for identifying priming agents comprising:
- a. contacting a test-cancerous cell and a non-cancerous cell with a plurality of priming agent candidates;
- b. assaying surface marker expression on both the test-cancerous cell and the non-cancerous cell in response to the priming agent candidates, and further assaying surface marker expression on a control-cancerous cell that was not contacted with priming agent candidates;
- and
- c. identifying priming agent candidates that increase surface marker expression on the test-cancerous cell compared to both the control-cancerous cell and the non-cancerous-control cell as priming agents.
Dependencies are inferred from the claim text.