US 2020/0046723 A1 · Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity

Abstract

A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Claims13

Dependent claims

A compound of formula (I), or a pharmaceutically acceptable salt thereof:

wherein
X represents N or C—F;
R1 represents hydrogen or methyl;
R2 represents hydrogen, methyl or trifluoromethyl;
and R3 represents hydrogen, cyano, hydroxy or hydroxymethyl.

2 more elements

Dependencies are inferred from the claim text.

Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity

Life of this patent

Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity

Life of this patent

Abstract

Claims13