Process for making 1,3,7- trimethyluric acid water soluble salts or co-crystals and their usage in dietary supplements or functional foods formulations

Abstract

The disclosure provides palatable nutritional supplements, foods cosmetic or pharmaceutical acceptable compositions that can be administrated orally, topically or parenterally in a solid, aqueous, cream, gel or ointment dosage form, containing one or more of the purine alkaloids bioactive compounds including 1,3,7-trimethyluric acid salts, for example water soluble mineral salts thereof such as 1,3,7-trimethyluric acid sodium, calcium, magnesium, potassium salts but not limited to these or salts in a form of citrates, malates, glutarates, fumarates, adipates, phosphates, nitrates, hydrochlorites, sulfates, succinates, acetates salts but not limited to these; it also provide compositions and usage of 1,3,7-trimethyluric acid, 1,7-dimethyluric acid, 1-methyluric acid, 9-methyluric acid, 3,7-dimethyluric acid in a form of salts or co-crystals that is easily soluble in water and not bitter or easily to be masked and flavored when dissolved in a natural or artificial flavored powder drink mix or a ready to drink natural or artificial flavored aqueous formulation.

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