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US 2020/0046710 A1Published application
Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
AssigneeVasopharm GmbH
InventorsPeter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
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Abstract
The present invention relates to a method of a method of treating a disease in a subject.
Claims17
A method of treating a disease in a subject, comprising the step of administering to a subject in need thereof a solid pharmaceutical composition comprising
- a) a compound having the formula (I):
- and/or a compound having the formula (II):
- and
- b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4.2 H2O and Na2HPO4.2 H2O, and wherein the quantity of the NaH2PO4.2 H2O and Na2HPO4.2 H2O present in the composition is chosen such that the molar ratio of both NaH2PO4.2 H2O and Na2HPO4.2 H2O to compound (I) or compound (II) ranges from 0.02 to 0.5, with the proviso that the composition does not include an antioxidant,
- wherein the disease is selected from the group consisting of traumatic brain injury, non-traumatic brain injury, elevated cranial pressure, and secondary brain injury.
2 more elements
The method of claim 11, comprising reconstituting the lyophilized pharmaceutical composition in a pharmaceutically acceptable fluid to form an injectable solution.
The method of claim 12, wherein the injectable solution is administered to the subject by infusion or injection.
Dependencies are inferred from the claim text.