Back to results
US 2020/0046707 A1Published application
Topical formulation for a jak inhibitor
AssigneesIncyte Corporation, Incyte Holdings Corporation
InventorsBhavnish Parikh, Bhavesh Shah, Krishnaswamy Yeleswaram
Life of this patent
Estimating the term…
Abstract
This invention relates to pharmaceutical formulations for topical skin application comprising (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, or a pharmaceutically acceptable salt thereof, and use in the treatment of skin disorders.
Claims21
1-82. (canceled)
A composition, comprising:
- an oil-in-water emulsion, comprising:
- water,
- an oil component,
- an emulsifier component,
- a solvent component, and
- from about 0.5% to about 1.5% by weight of the emulsion on a free base basis of 1:1 (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d,]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid salt,
- wherein the oil-in-water emulsion is a solubilized cream for topical skin application for reversing the symptomatology of a skin disorder in a human in need thereof and
- further wherein said oil-in-water emulsion has a pH of not greater than 3.6.
5 more elements
A composition comprising:
- an oil-in-water emulsion, comprising:
- water,
- an oil component,
- an emulsifier component,
- a solvent component, and
- from about 0.5% to about 1.5% by weight of the emulsion on a free base basis of 1:1 (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d,]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid salt,
- wherein the oil-in-water emulsion is a solubilized cream for topical skin application for reversing the symptomatology of a skin disorder in a human in need thereof and
- further wherein said oil-in-water emulsion has a pH of 2.9 to 3.6.
5 more elements
Dependencies are inferred from the claim text.