US 2020/0046706 A1 · Composition for Inducing Differentiation and Protection of Neural Stem Cells and Method for Inducing Neuro-Regeneration Using the Same Composition

Abstract

The present invention relates to a method of inducing neuro-regeneration comprising administering a MEK 1/2 inhibitor to a patient in need thereof. In the present invention, the MEK1/2 inhibitor induces neuro-regeneration by differentiating neural stem cells into neurons, by protecting neural stem cells and neurons against cytotoxicity of amyloid-betas, or by both of the above. Also, the present invention relates to a method of protecting neurons against neuronal loss or damage comprising administering a MEK1/2 inhibitor. In addition, this invention relates to a method of preventing or treating neurodegenerative disease due to neuronal loss or damage for patients in need thereof comprising administering a MEK 1/2 inhibitor.

Claims11

Dependent claims

A method of treating a neurodegenerative disease, comprising the step of:

administering trametinib to a patient diagnosed with the neurodegenerative disease, wherein the neurodegenerative disease is selected from the group consisting of:
dementia, vascular dementia, senile dementia, frontotemporal dementia, Lewy body dementia, Parkinson's disease, multiple system atrophy, corticobasal degeneration, progressive supranuclear palsy, Huntington's disease, amyotrophic lateral sclerosis (ALS or Lou-Gehrig's disease), primary lateral sclerosis, progressive bulbar palsy (PBP), progressive muscular atrophy (PMA), pseudobulbar palsy, hereditary spastic paraplegia (HSP), cerebellar ataxia, Creutzfeldt-Jakob disease, multiple sclerosis, and Guillain-Barré syndrome.

Dependencies are inferred from the claim text.

Facts

Application

16/545,438Filed 20 Aug 2019

Priority

KR 10-2016-015873925 Nov 2016

Published

13 Feb 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

A61K 31/519
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with heterocyclic rings
A61P 25/16
For treating abnormal movements, e.g. chorea, dyskinesia: anti-Parkinson drugs
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
A61K
Medicines and medical preparations

Family

Application15/897,138Division · filed 14 Feb 2018

Application16/545,438Division

Application15/897,138Continuation

US 10,485,802 B2Related patent

US 11,147,816 B2Related patent

US 2018/0169102 A1Published application

US 2020/0046706 A1This patent

From the US filing history. Foreign family members aren’t listed.

Composition for Inducing Differentiation and Protection of Neural Stem Cells and Method for Inducing Neuro-Regeneration Using the Same Composition

Life of this patent

Composition for Inducing Differentiation and Protection of Neural Stem Cells and Method for Inducing Neuro-Regeneration Using the Same Composition

Life of this patent

Abstract

Claims11