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US 2020/0046697 A1Published application
Inhibitor of indoleamine-2,3-dioxygenase (ido)
AssigneeInventisbio Co., Ltd.
InventorsXing DAI, Yaolin WANG
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
Claims30
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- W is —O—, —S—, or a bond;
- Q is —C(═O)NH— or a bond;
- Y is —CR8═ or —N═, as valency permits;
- R1 is —C(═O)OH, —C(═O)OR10, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroaryl, —NHSO2R9, —C(═O)NHSO2R9, —C(═O)NHC(═O)OR10, or —SO2NHC(═O)R10;
- R2 and R3 are each independently hydrogen, halogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, or R2 and R3 are joined to form a substituted or unsubstituted 3- to 8-membered carbocyclic ring, or substituted or unsubstituted 3- to 8-membered heterocyclic ring;
- R4 and R5 are each independently hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C5-C8 cycloalkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted 5- to 6-membered monocyclic heteroaryl, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, substituted or unsubstituted aryl, or arylsulfonyl;
- or R4 and R5 are joined together with the N they are attached to to form optionally substituted, monocyclic or bicyclic, heterocyclyl;
- R6 is substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C8 cycloalkyl;
- substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C5-C8 cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted 4- to 7-membered monocyclic heterocyclyl, substituted or unsubstituted 7- to 10-membered bicyclic heterocyclyl, substituted or unsubstituted 5- to 6-membered monocyclic heteroaryl, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted aryloxy, or —C(═O)R7;
- R7 is hydrogen, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted aryl;
- R8 is hydrogen, halogen, —CN, —OH, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C1-C6 alkoxy;
- and
- R9 and R10 are each independently hydrogen, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C2-C6 alkenyl.
12 more elements
3-6. (canceled)
(canceled)
(canceled)
(canceled)
(canceled)
16-20. (canceled)
23-25. (canceled)
27-30. (canceled)
(canceled)
Dependencies are inferred from the claim text.