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US 2020/0046695 A1Published application
Oral pharmaceutical composition of lurasidone and preparation thereof
AssigneePiramal Enterprises Limited
InventorsTejas SHAH, Milan B. AGRAWAL, Narendra PATEL, Devesh BHATT, Umesh BARABDE, Vipan DHALL
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Abstract
The present invention relates to an oral pharmaceutical composition, particularly a tablet, comprising an active ingredient lurasidone or its pharmaceutically acceptable salt(s) or solvate(s) thereof and one or more pharmaceutical excipient(s); and a process for its preparation.
Claims21
An oral pharmaceutical composition comprising:
- (a) lurasidone or its pharmaceutically acceptable salt(s) or solvate(s) thereof,
- (b) microcrystalline cellulose and,
- (c) one or more other pharmaceutical excipient(s);
- wherein the ratio of lurasidone to microcrystalline cellulose is in the range from about 2:1 to about 10:1.
1 more element
A process for preparing an oral pharmaceutical composition containing a therapeutically effective amount of lurasidone or its pharmaceutically acceptable salts or solvates thereof comprising:
- combining lurasidone or its pharmaceutically acceptable salts or solvates with one or more pharmaceutically acceptable excipient(s) wherein;
- lurasidone or its pharmaceutically acceptable salts or solvates and said pharmaceutically acceptable excipient(s) are granulated using 40% to 250% of granulating solution by top spray granulation process.
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Dependencies are inferred from the claim text.