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US 2020/0046686 A1Published application
Medicament containing pemafibrate
AssigneeKowa Company, Ltd.
InventorsSatoshi KOJIMA, Ryohei TANIGAWA
Life of this patent
Estimating the term…
Abstract
To provide an appropriate method of treatment with pemafibrate for a liver cirrhosis patient. The present invention relates to the use of pemafibrate in a liver cirrhosis patient. More particularly, the present invention relates to a regimen for administering a reduced dose of pemafibrate to a liver cirrhosis patient in need of treatment with pemafibrate than to persons with normal liver function.
Claims12
1-26. (canceled)
27:
- A method of treating a liver cirrhosis patient with pemafibrate, comprising administering a medicament comprising pemafibrate, a salt thereof, or a solvate thereof at a dose lower than the dose for a person with normal liver function.
28:
- The method according to claim 27, for treating at least one disease selected from the group consisting of hyperlipemia, dyslipidemia, dyslipidemia, arterial sclerosis, diabetes mellitus, diabetic complications, inflammation, non-alcoholic steatohritis, primary biliary circulation and heart disease.
29:
- The method according to claim 27, wherein the medicament comprising pemafibrate, a salt thereof, or a solvate thereof is a medicament comprising pemafibrate.
30:
- The method according to claim 27, comprising administering the medicament to a mild liver cirrhosis patient at a dose of ½ or less of the dose for a person with normal liver function.
31:
- The method according to claim 27, comprising administering the medicament as 0.1 mg to 0.2 mg of pemafibrate per day to a mild liver cirrhosis patient.
32:
- The method according to claim 27, comprising administering the medicament as 0.05 mg of pemafibrate twice per day to a mild liver cirrhosis patient.
33:
- The method according to claim 27, comprising administering the medicament as 0.1 mg of pemafibrate twice per day to a mild liver cirrhosis patient.
34:
- The method according to claim 27, comprising administering the medicament to a moderate liver cirrhosis patient at a dose of ¼ or less of the dose for a person with normal liver function.
35:
- The method according to claim 27, comprising administering the medicament as 0.05 mg to 0.1 mg of pemafibrate per day to a moderate liver cirrhosis patient.
36:
- The method according to claim 27, comprising administering the medicament as 0.025 mg of pemafibrate twice per day to a moderate liver cirrhosis patient.
37:
- The method according to claim 27, comprising administering the medicament as 0.05 mg of pemafibrate twice per day to a moderate liver cirrhosis patient.