Compounds, compositions, and methods for inhibiting bacterial growth
AssigneeBoard of Trustees of Michigan Stat University
InventorsRobert ABRAMOVITCH, Huiqing ZHENG, Christopher J. COLVIN, Benijamin K. JOHNSON
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Abstract
The present disclosure provides, among other things, compounds, compositions, and methods useful in inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted with active or latent bacterial infections.
Claims127
A method for inhibiting growth of one or more bacterial cells in which an at least two-component regulatory system is conserved, said two-component regulatory system comprises one or more sensor histidine kinase and a cognate response regulator, the method comprising contacting the one or more bacterial cells with an effective amount of a compound that inhibits the at least two component regulatory system to thereby inhibit the growth of the one or more bacterial cells.
A method for preventing or reducing the likelihood of a productive bacterial infection in a subject, the method comprising administering to a subject an effective amount of a compound that inhibits an at least two-component regulatory system, said two-component regulatory system comprises one or more sensor histidine kinase and a cognate response regulator, to thereby prevent or reduce the likelihood of a productive bacterial infection in the subject, wherein the subject has been identified as being at risk of developing an infection with bacterial cells in which the at least two-component regulatory system is conserved.
A method for treating a subject who is infected with bacterial cells in which an at least two-component regulatory system is conserved, said two-component regulatory system comprises one or more sensor histidine kinase and a cognate response regulator, the method comprising administering to the subject an effective amount of a compound that inhibits the at least two-component regulatory system to thereby treat the infection.
A method for ameliorating the signs or symptoms of an infection of a subject by bacterial cells in which the at least two-component regulatory system is conserved, said two-component regulatory system comprises one or more sensor histidine kinase and a cognate response regulator, the method comprising administering to the subject an effective amount of a compound that inhibits the at least two-component regulatory system to thereby ameliorate the signs and symptoms of the infection.
The method of any one of claim 83 or 85, wherein A16 is NH.
A method for treating tuberculosis in a subject, the method comprising administering to the subject a compound that inhibits a DosRST two-component regulatory system and/or DosRST regulon in an amount effective to treat tuberculosis.
A method for eliminating dormant Mycobacterium tuberculosis cells in a subject afflicted with latent tuberculosis, the method comprising administering to the subject an effective amount of compound that inhibits a DosRST two-component regulatory system and/or DosRST regulon to thereby eliminate dormant Mycobacterium tuberculosis cells in the subject and treat latent tuberculosis.
Dependencies are inferred from the claim text.