Methods for decreasing injuries associated with intraoperative hypotension
AssigneeResQ Pharma, Inc.
InventorGuy Weinberg
Life of this patent
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Abstract
The present disclosures provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.
Claims30
1-2. (canceled)
A method for decreasing myocardial injury or acute kidney injury in a subject following intraoperative hypotension, the method comprising intravenously administering to the subject a therapeutically effective amount of a fat emulsion after the subject's mean arterial pressure (MAP) is recovered to greater than or equal to 66 mgHg,
- wherein administration of the therapeutically effective amount of the fat emulsion results in at least a 10% decrease in a marker of myocardial injury or acute kidney injury as compared to a control group that did not receive the fat emulsion,
- wherein the marker of myocardial injury is cardiac troponin or heart-type fatty acid binding protein, or wherein the marker of acute kidney injury is creatinine or lipocalin-2.
6-10. (canceled)
A method for decreasing postoperative myocardial infarction in a subject following intraoperative hypotension,
- the method comprising intravenously administering to the subject a therapeutically effective amount of a fat emulsion after the subject's mean arterial pressure (MAP) is recovered to greater than or equal to 66 mgHg,
- wherein administration of the therapeutically effective amount of the fat emulsion results in at least a 10% decrease in a postoperative myocardial infarction as compared to a control group that did not receive the fat emulsion.
12-13. (canceled)
A method for decreasing postoperative mortality in a subject who will undergo surgery, the method comprising intravenously administering to the subject, before surgery begins, a therapeutically effective amount of a fat emulsion, wherein mortality is reduced by at least 10% as compared to a control group that did not receive the fat emulsion.
A method for decreasing postoperative mortality in a subject following intraoperative hypotension, the method comprising intravenously administering to the subject a therapeutically effective amount of a fat emulsion after the subject's mean arterial pressure (MAP) is recovered to greater than or equal to 66 mgHg, wherein mortality reduced by at least 10% as compared to a control group that did not receive the fat emulsion.
16-17. (canceled)
The method of 18, wherein the decrease is at least 20%, at least 30%, or at least 50%.
20-50. (canceled)
A method for decreasing 30-day or one year mortality following general anesthesia for a subject whose has intraoperative hypotension while under general anesthesia, the method comprising intravenously administering to a subject a therapeutically effective amount of a fat emulsion after the subject has received one or more reperfusion therapies to restore mean arterial pressure (MAP) to 66 mgHg or higher, wherein the subject is not in shock at the time the fat emulsion is administered.
(canceled)
54-60. (canceled)
62-67. (canceled)
(canceled)
Dependencies are inferred from the claim text.