Pharmaceutical composition for inducing exercise mimetic effect

Abstract

The present disclosure relates to a pharmaceutical composition for inducing an exercise mimetic effect, which contains an α1-adrenergic receptor agonist as an active ingredient, and a method for screening a drug for inducing an exercise mimetic effect using the α1-adrenergic receptor agonist. The α1-adrenergic receptor agonist of the present disclosure increases the expression of p-AMPK, PPARδ and PGC-1α, which play key roles in maintaining and regulating energy metabolic activity in vivo, thereby increasing glucose uptake into skeletal muscle cells, suppressing adipocyte differentiation and lipid accumulation, reducing abdominal fat and body weight as well as regulating mitochondrial metabolic disorders and suppressing inflammatory responses. Accordingly, the α1-adrenergic receptor agonist can be usefully used to prevent and treat diseases requiring AMPK activation (metabolic diseases, cardiovascular diseases, inflammatory disease, etc.).

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