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US 2020/0046656 A1Published application
Stable aqueous capsaicin injectable formulations and medical uses thereof
AssigneeCentrexion Therapeutics Corporation
InventorsDrazen OSTOVIC, Gary Fred MUSSO
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Abstract
The invention provides stable, aqueous capsaicin injectable formulations, a unit dose containing such injectable formulations, medical kits, and methods for using such injectable formulations and unit doses to treat patients suffering from pain, such as osteoarthritic knee pain. The stable, aqueous capsaicin injectable formulations may contain, for example, capsaicin, a solubilizing agent (e.g., a polyethylene glycol ester of a (C15-C25) hydroxyalkanoic acid), an antioxidant, and water.
Claims100
An aqueous, capsaicin injectable formulation, comprising
- a. about 0.03% (w/w) to about 0.3% (w/w) of capsaicin;
- b. about 0.1% (w/w) to about 3% (w/w) of a solubilizing agent, wherein the solubilizing agent comprises (i) a polyethylene glycol ester of a (C15-C25) hydroxyalkanoic acid, (ii) a polyethylene glycol ester of a (C15-C25) hydroxyalkenoic acid, or (iii) a polyethylene glycol ester of a (C15-C25) alkanoic acid substituted by a —OC(O)(C14-C24) hydroxyalkyl group;
- c. about 0.001% (w/w) to about 2% (w/w) of an antioxidant;
- and
- d. at least 92% (w/w) water.
2 more elements
56-75. (canceled)
99-107. (canceled)
Dependencies are inferred from the claim text.