Iron chelator therapy method
OwnerGeoffrey C. Gurtnerinventor
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Abstract
Compositions and methods are provided for the prevention and treatment of chronic wounds such as pressure ulcers by transdermal delivery of an agent that increases activity of HIF-1alpha in the wound. Wound healing ability reduced in aged subjects can be restored by use of the iron chelator formulations and methods to be similar to that of young subjects.
Claims38
A method for restoring wound healing ability in a subject having a reduced wound healing ability due to age, comprising:
- delivering an effective amount of an iron-chelating compound to the subject;
- increasing HIF-1alpha expression in the subject;
- and
- restoring the wound healing ability of the subject.
The method of claim 1, wherein the iron-chelating compound is delivered in a formulation of claim 22.
A formulation for transdermal delivery of an iron-chelating compound, comprising an extended release formulation comprising a biodegradable polymer.
Dependencies are inferred from the claim text.