Exosome-based nanoparticle composite and method for preparing the same
AssigneeKorea University Research and Business Foundation, Sejong Campus
InventorSoon Hong YUK
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Abstract
The present invention relates to an exosome-based nanoparticle composite and a method for preparing the same. More specifically, the present invention relates to an exosome-based nanoparticle composite that uses exosomes isolated from cells and a biocompatible polymer to achieve improved in vivo stability and redispersibility, and a method for preparing the nanoparticle composite. The nanoparticle composite of the present invention exhibits a stable and continuous drug release pattern irrespective of the solubility of the drug and has excellent tumor targeting due to its good in vivo stability and improved redispersibility in aqueous solution.
Claims11
A core/shell nanoparticle composite comprising cell line-derived, drug-loaded exosome cores and PEO-PPO-PEO copolymer shells associated on the surface of the cell line-derived exosome cores.
A method for preparing a core/shell nanoparticle composite, comprising (a) isolating exosomes from a cell line by centrifugation, (b) mixing the isolated exosomes with a drug to load the drug into the exosomes, and (c) mixing the drug-loaded exosomes with an aqueous solution of a PEO-PPO-PEO copolymer, followed by freeze-drying.
Dependencies are inferred from the claim text.