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US 2020/0046313 A1Published application
Non-invasive method for pressure measurement
AssigneesThomas Jefferson University, Ge Healthcare Limited
InventorsFlemming Forsberg, David Mills, John R. Eisenbrey, Kirk Wallace, Ipshita Gupta
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Abstract
The present invention relates to the use of contrast-enhanced ultrasound using microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in a region of interest (ROI) of a subject. The method of the invention provides a non-invasive, direct, and accurate method for pressure estimation.
Claims31
A method for obtaining a pressure measurement in at least one region of interest (ROI) in a subject wherein said method comprises:
- administering a diagnostically effective amount of a microbubble ultrasound contrast agent (UCA) to said subject;
- allowing said UCA to accumulate in said subject;
- transmitting an ultrasonic wave to said ROI in said subject wherein said ultrasonic wave is a broadband wave;
- optimising the acoustic power for said ultrasonic wave;
- receiving an ultrasonic echo generated by reflecting the ultrasonic wave transmitted in step (iii) from said ROI thereby acquiring a detection signal;
- extracting a sub-harmonic component from the ultrasonic echo based on the detection signal;
- and
- using the inverse linear relationship between the subharmonic signal amplitude and the ambient pressure to obtain said pressure measurement.
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