System, method, and computer readable medium for a basal rate profile adaptation algorithm for closed-loop artificial pancreas systems

A computer-implemented method to control an insulin dosage by adapting a basal rate profile, the method comprising:

• producing a blood glucose level measurement data;
• detecting changes of the blood glucose level measurement data over time;
• receiving the blood glucose level measurement data and a basal rate profile, wherein the basal rate profile includes a basal rate set point that corresponds to an insulin delivery reference for a nominal blood glucose, and wherein the basal rate profile is stored in the computer memory device;
• administering insulin in accordance with the received basal rate profile;
• updating the basal rate set point over a time period based on both an assessment of at least one of a risk of hyperglycemia and a risk of hypoglycemia from historical blood glucose data, and patterns of actions taken by the insulin device to mitigate glycemic risk during the time period;
• and
• controlling an insulin dispensing device to provide insulin dosing based on the updated basal rate set point.

A non-transitory computer readable recording medium encoded with a computer program comprising program instructions for causing an insulin device to control an insulin dosage by adapting a basal rate profile, the computer program causing the insulin device to:

• produce a blood glucose level measurement data;
• detect changes of the blood glucose level measurement data over time;
• receive the blood glucose level measurement data and a basal rate profile, wherein the basal rate profile includes a basal rate set point that corresponds to an insulin delivery reference for a nominal blood glucose, and wherein the basal rate profile is stored in the computer memory device;
• administer insulin in accordance with the received basal rate profile;
• update the basal rate set point over a time period based on both an assessment of at least one of a risk of hyperglycemia and a risk of hypoglycemia from historical blood glucose data, and patterns of actions taken by the insulin device to mitigate glycemic risk during the time period;
• and
• control an insulin dispensing device to provide insulin dosing based on the updated basal rate profile.