Swine Comprising Modified CD163 and Associated Methods
AssigneeThe University Court of the University of Edinburgh
InventorsSimon Geoffrey Lillico, Alan Archibald, Christopher Bruce Alexander Whitelaw, Christine Tait-Burkard, Tahar Ait-Ali
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Abstract
The present invention relates to genetically edited swine which produce CD163 protein in which the scavenger receptor cysteine-rich 5 (SRCR5) domain (also known as CD163 domain 5) has been deleted. Such swine have been found to be healthy and do not exhibit negative properties, and are resistant to PRRSV infection. CD163 expressed in the edited swine also demonstrates retention of the ability to function as a haemoglobin-haptoglobin scavenger. Methods of producing such swine are also provided.
Claims39
A genetically edited swine, the swine comprising an edited genome wherein the edit results in the deletion of SRCR5 domain from the CD163 protein produced by the swine.
A genetically edited swine cell or embryo, wherein the edit results in the deletion of SRCR5 domain from the CD163 protein that can be produced by the swine cell or embryo.
A method of producing a genetically edited swine, the method comprising the steps of:
- a) providing a swine cell;
- b) editing the genome of the cell to create a genome modification which results in the deletion of SRCR5 from the CD163 protein;
- and
- c) generating an animal from said cell.
(canceled)
39-44. (canceled)
Dependencies are inferred from the claim text.