Treatment of gluten intolerance and related conditions
AssigneeNepetx, LLC
InventorsDavid C. SCHRIEMER, Petr MAN, Hynek MRAZEK, Martial REY
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Abstract
Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease. Further provided herein are pharmaceutical compositions comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof to treat bacterial infections of the gastrointestinal tract, such as C. difficile or H. pylori. Further provided herein are compositions comprising recombinant nepenthesin I or nepenthesin II, or homologous proteins, and methods for making the same.
Claims21
1-12. (canceled)
A composition for treating or attenuating gluten intolerance comprising:
- (a) an effective amount of nepenthesin, the nepenthesin having an amino acid sequence that is at least 85% identical to an amino acid sequence selected from SEQ ID NO.:
- 3, SEQ ID NO.:
- 4, SEQ ID NO.:
- 5, SEQ ID NO.:
- 6, and SEQ ID NO:
- 7, without a plant signal sequence and having aspartic protease activity;
- and
- (b) an effective amount of a buffer to maintain the pH of said composition at a pH of 5 or above, wherein said nepenthesin is inactive prior to administration;
- wherein said effective amount of nepenthesin is sufficient to degrade gluten upon oral administration of said solid composition to a patient suffering from gluten intolerance.
A method for treating or attenuating gluten intolerance, celiac disease, wheat allergy, or dermatitis herpetiformis in a patient in need thereof, comprising administering to said patient an effective amount of nepenthesin, wherein said nepenthesin comprises an amino acid sequence that is at least 85% identical to the amino acid sequence set forth in SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, or SEQ ID NO:
- 7, such that gluten is degraded by the nepenthesin, thereby treating or attenuating gluten intolerance, celiac disease, wheat allergy, or dermatitis herpetiformis in the patient.
Dependencies are inferred from the claim text.